The twin-engine plane came apart and caught fire mid-flight, witnesses told local media, before crashing in Yorba Linda, a suburb of Los Angeles.
Twitter user, JoshuaRNelson posted a video shortly after 2pm of what appears to be burning plane parts on a residential street.
The aircraft involved was a Cessna 414A Chancellor, an 8-seat twin-engine plane.
The Orange County Fire Authority said crews were responding to two homes.
The Federal Aviation Administration (FAA) and the National Transportation Safety Board (NTSB) will investigate.
Alex Gallardo AP
Just after 2 p.m., the OCFA authority confirmed that there were at least two active house fires on Canyon Drive.
The wounded were taken to a hospital with burn injuries, said Pokey Sanchez, an assistant chief with the Orange County Fire Authority. He says the deceased occupants of the home were two males and two females.
Another tweeted: "Pretty sure we just saw a plane crash into a neighborhood". The number of people who were aboard the aircraft remains unclear. "I thought a bomb was dropped or something cuz I heard a plane engine moving in close and then my house shook on impact". No other identifying information such as names or ages was immediately released.
Aerial footage taken from news helicopters show plane parts, including side panels and a propeller, scattered on rooftops and driveways near the burned house.
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